Something has been attacking a remote cabin in Northern and it may have left behind a blood trail. DNA analysis suggested that the creature is a non-human primate. Now a follow up test will confirm or deny this, and the results could change history. Meanwhile, a new expedition, outfitted with the most advanced surveillance and detection equipment, will set up camp at the cabin and wait for the creature's imminent return.

You gotta love how advertising works and the way people buy it

This does sound intriguing.
And off-topic, but MYM's crazy-mouthed Gary Busey avatar sayin' "dealio" freaks me out.

... How significant would it be if MonsterQuest's follow up DNA test confirms that it belongs to a non-human primate?

I see your Gary Busey and raise you one Nick Nolte...

I see your Gary Busey and raise you one Nick Nolte...

MonsterQuest revisits the cabin located at Snelgrove Lake in Ontario to conduct further BF research.

Here's the History Channel's description of the episode:
The results could change history?
How significant would it be if MonsterQuest's follow up DNA test confirms that it belongs to a non-human primate?

......Apparently the follow up test with a larger segment didn't confirm the finding or we should have heard something about it considering "the results could change history". The fuss was based on a single nucleotide polymorphism or a single base pair or letter. Leaving that unconfirmed for this long really sounds like a dishonest attempt to push up the ratings. I didn't see it so I assume they left the question open or didn't confirm nonhuman DNA?.....

......The tissue and blood samples were first examined for DNA by Dr. Todd Disotel. He could find NO DNA and said he thought it had all been degraded. Then Dr. Nelson (a microbiologist) tried his hand at it, concluded that something was inhibiting the testing, and isolated out the galvanizing substance from the screws. Then he was able to obtain DNA and sequence it. His finding was for human, but with one variance that appears in chimpanzee, not human, DNA. Dr. Nelson said that he will perform additional tests over the next year, and that he thinks perhaps his results may show Bigfoot to be some sort of human.......

......Jeff Meldrum gave such answers to Dmitri Bayanov's questions:

1. Why did it take so long to announce the breakthrough result?

It is not really "breakthrough." We are talking about a mere 300 base pair sequence. This is extremely small sample -- nothing near a publishable result which would be many thousands of nucleotides. I was unaware that Curt felt confident that more sequence could be attained. I need to discuss this with him as well as see to follow-up of the hair identification

2. How solid is the lab that did the DNA testing? Did other labs confirm the finding? Will it be challenged by skeptics?

Curt is an excellent scientist and very capable. Of course it will be challenged. It is extremely preliminary and tentative. The best we could hope is that it will spark some interest and possible attract some funding to follow-up.........

...........Narrator: Dr. Curt Nelson has also been doing DNA tests on the blood, hair, and tissue samples and suspects there is an unknown substance, or inhibitor, present that is interfering with the DNA extraction. Nelson must first identify the inhibitor and remove it from the sequence. The inhibitor has been identified. The galvanizing on the screws was mixed in with the animal DNA. Nelson can now nudge DNA from the purified samples.

Nelson: Scientific evidence, at this point, is now suggesting there really is an animal there. I cut it out, I re-purified it, and amplified it again using the same primers, and I got a very strong reaction. When I did that I got rid of the inhibitory stuff by running it out that way. And I found it was identical to human DNA, except it had one nucleotide polymorphism. That nucleotide that was different was a difference that is shared with chimpanzees. I got DNA that was primate DNA, and I knew that I might be looking at the DNA of a sasquatch.

Narrator: The DNA says primate, but not quite human and not quite nonhuman primate. One of the base pairs is deviated.

Nelson: What we have to do now is look at more DNA. We have to sequence more of it. We have to design primers to amplify different regions of the DNA so that we can get sequence across the mitochondrial genome and determine whether or not it is just human DNA, which seems unlikely that something -- like a human -- would step on that board like that.

Narrator: Great apes share nearly identical DNA with man except for a 35-base-pair deviation. The Snellgrove DNA sample has only 1 deviation. According to Nelson, there is only a 1 in 5,000 chance this is human DNA.

Nelson: What we're looking at is the blood so far. So if we can find that same sequence exists in the tissue and hair, that indicates that an animal that bled there and left the tissue there and the hair there was all the same animal, and produce the same sequence. That's important to tie it all together. And that could take a year..........

Now, does hair incompatible with bear, human, or other local fauna found along with the blood DNA on the screwboard that also is incompatible with bear, human, or other local fauna constitute enough "evidence" to warrant the very first funding from government, academia, or science institute to look further into the matter?

Nah. Just like in so many similar previous cases, it isn't "compelling", "conclusive", "decisive", "definitive", "irrefutable", "telling", "convincing", or *insert qualifying adjective here* enough, and multiple cases like this don't count.

No more screw boards. Is a spring gun or Claymore mine necessary?

Thanks. Part of this is my classic act. Overemphasize, dramaticize, and keep pounding the point home is one of my favorite tactics.

I'm not really this crazy. I just look, sound, behave, and maintain myself like that.

I am not sure when that one will air, but I do know that the episode on China's Wildman featuring Dr. Jeff Meldrum is scheduled to air on a Sunday night, September 14th, at 9:00 EST. Then, on September 17th, is an episode on Lake Monsters of the North, focusing particularly on "Chessie" and other Denizens of the lakes.

Apparently the galvanized screws contaminated the initial attempts to analyze the DNA:
Now, does hair incompatible with bear, human, or other local fauna found along with the blood DNA on the screwboard that also is incompatible with bear, human, or other local fauna constitute enough "evidence" to warrant the very first funding from government, academia, or science institute to look further into the matter?

Nah. Just like in so many similar previous cases, it isn't "compelling", "conclusive", "decisive", "definitive", "irrefutable", "telling", "convincing", or *insert qualifying adjective here* enough, and multiple cases like this don't count.

No more screw boards. Is a spring gun or Claymore mine necessary?

Oh darn it, missed it again! Why do all the good shows have to come on when I have my only chance to swim and work out! Dang, dang, dang!

.....If they are close enough to hybridize with us, then it is not impossible that in the far past (perhaps even still in Asia) a BF-like male and human-like female had offspring, ......

.....A wildwoman named Zana is said to have lived in the isolated mountain village of T'khina fifty miles from Sukhumi in Abkhazia in the Caucasus; some have speculated she may have been an Alma, but hard evidence is lacking.

Captured in the mountains in 1850, she was at first violent towards her captors but soon became domesticated and, indeed, was able to assist with simple household chores. Zana is said to have had sexual relations with a man of the village named Edgi Genaba, and gave birth to a number of children of apparently normal human appearance. Several of these children, however, died in infancy. Some commentators have attributed these early deaths to Zana's genetic incompatibility (as an Almas) with humans.

The father, meanwhile, gave away four of the surviving children to local families. The two boys, Dzhanda and Khwit Sabekia (born 1878 and 1884), and the two girls, Kodzhanar and Gamasa Sabekia (born 1880 and 1882), were assimilated into normal society, married, and had families of their own. Zana herself died in 1890. The skull of Khwit (also spelled Kvit) is still extant, and was examined by Dr. Grover Krantz in the early 1990s. He pronounced it to be entirely modern, with no Neanderthal features at all. Khwit's tooth was examined in 2008 as part of the Monster Quest tv show. Genetics tests were unable to definitely show Khwit's parentage, but tests will continue.......

If they are close enough to hybridize with us, then it is not impossible that in the far past (perhaps even still in Asia) a BF-like male and human-like female had offspring

I don't think the show was hoaxed.

I find it quite hard to believe that the "bigfoot fanatic" faked results. I rather doubt he did anything wrong but I am not an overly suspicious type. Someone on the show did seem to misinterpret the DNA results as something other than DNA apparently from a modern human. I will tend to give the scientist the benefit of the doubt and attribute sensationalism to those that edit the show unless I hear otherwise even when the scientist seemed to misstate things. I seem to remember someone saying there was a 1 in 5000 chance of it being human DNA but that just didn't make any sense in that context. That sort of distortion or sensationalism does hurt the credibility of the show. It should hurt the credibility of the scientist in my opinion if he said it and it wasn't taken out of context.